Monoclonal anibodies to human progesterone receptors
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چکیده
منابع مشابه
Monoclonal antibodies to rabbit progesterone receptor: crossreaction with other mammalian progesterone receptors.
A mouse was immunized with purified rabbit uterine cytosolic progesterone receptor (specific activity: 3 nmol of steroid bound per mg of protein). After fusion of its spleen cells with Sp2-OAg myeloma cells, supernatants of 11 hybrid cultures were found to react in both an immunoenzymatic test and a double-immunoprecipitation test with the progesterone receptor. Clones were obtained from the fi...
متن کاملProgesterone receptors on human spermatozoa.
Progesterone, primarily recognized as a female steroid hormone, is reported to affect several sperm functions especially capacitation, motility and acrosome reaction. These effects of progesterone on the spermatozoa are mediated via the progesterone binding sites/progesterone receptor (PR) on the acrosomal membrane. These receptors in response to progesterone increase the intercellular Ca2+ lev...
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Alpha-fetoprotein (AFP), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. Monoclonal anti-AFP antibodies are essential reagents in developing appropriate techniques for measurement of this protein. In this study, in order to produce anti-AFP monoclonal a...
متن کاملImmunocytochemical Localization of Progesterone Receptors in Breast Cancer with Anti-Human Receptor Monoclonal Antibodies1
Monoclonal antibodies (MAhs). recently produced against human progesterone receptors (PR), were used for immunocytochemical local ization of PR. The specificity of the immunocytochemical assay for PR was demonstrated by incubation with control M Mis. preabsorption of M Alis with highly purified human PR, and by the cell and tissue distribution of the immunostaining reaction. With human breast c...
متن کاملImmunocytochemical localization of progesterone receptors in breast cancer with anti-human receptor monoclonal antibodies.
Monoclonal antibodies (MAbs), recently produced against human progesterone receptors (PR), were used for immunocytochemical localization of PR. The specificity of the immunocytochemical assay for PR was demonstrated by incubation with control MAbs, preabsorption of MAbs with highly purified human PR, and by the cell and tissue distribution of the immunostaining reaction. With human breast cance...
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ژورنال
عنوان ژورنال: Journal of Cancer Research and Clinical Oncology
سال: 1986
ISSN: 0171-5216,1432-1335
DOI: 10.1007/bf02580056